LISTSERV mailing list manager LISTSERV 16.0

Help for NET-GOLD Archives


NET-GOLD Archives

NET-GOLD Archives


NET-GOLD@LISTSERV.TEMPLE.EDU


View:

Message:

[

First

|

Previous

|

Next

|

Last

]

By Topic:

[

First

|

Previous

|

Next

|

Last

]

By Author:

[

First

|

Previous

|

Next

|

Last

]

Font:

Proportional Font

LISTSERV Archives

LISTSERV Archives

NET-GOLD Home

NET-GOLD Home

NET-GOLD  September 2008

NET-GOLD September 2008

Subject:

MEDICAL: RESEARCH : MEDICAL: DISEASES: New Pig Model of Cystic Fibrosis Lays Groundwork for Better Understanding of Human Disease

From:

"David P. Dillard" <[log in to unmask]>

Reply-To:

Net Gold Listserv List <[log in to unmask]>

Date:

Thu, 25 Sep 2008 17:50:32 -0400

Content-Type:

TEXT/PLAIN

Parts/Attachments:

Parts/Attachments

TEXT/PLAIN (195 lines)

MEDICAL: RESEARCH :
MEDICAL: DISEASES:
New Pig Model of Cystic Fibrosis Lays Groundwork for
Better Understanding of Human Diseas



Date: Thu, 25 Sep 2008 15:05:43 -0400
From: "NIH OLIB (NIH/OD)" <[log in to unmask]>
To: [log in to unmask]
Subject:  New Pig Model of Cystic Fibrosis Lays Groundwork for
Better Understanding of Human Disease



U.S. Department of Health and Human Services
NATIONAL INSTITUTES OF HEALTH NIH News


National Heart, Lung, and Blood Institute (NHLBI)
<http:// www.nhlbi.nih.gov/>


National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
<http://www.niddk.nih.gov/>



Embargoed for Release: Thursday, September 25, 2008, 2:00 p.m. EDT



CONTACT: NHLBI Communications Office

301-496-4236

e-mail:

[log in to unmask]




NEW PIG MODEL OF CYSTIC FIBROSIS LAYS GROUNDWORK FOR BETTER UNDERSTANDING OF HUMAN DISEASE



For the first time, researchers have developed a genetically altered 
animal model for cystic fibrosis (CF) that closely matches the 
characteristics of the disease in humans. By studying the complex and 
multi-organ disease process in the pig model, researchers can now better 
understand how the complications of CF develop, an advancement that may 
lead to new avenues for research in prevention and treatment.

The study, published in the Sept. 26 edition of "Science," was funded in 
part by the National Heart, Lung, and Blood Institute (NHLBI), along with 
the National Institute of Diabetes and Digestive and Kidney Diseases 
(NIDDK), both of the National Institutes of Health, as well as the Cystic 
Fibrosis Foundation.

CF is an inherited disease of the mucus-secreting glands which is caused 
by mutations in the gene responsible for making the protein cystic 
fibrosis transmembrane conductance regulator (CFTR), important for making 
sweat, digestive juices, and mucus. CF affects multiple organs, including 
the lungs, pancreas, liver, intestines, sinuses, and sex organs. In CF, 
mucus becomes thick and sticky, and builds up in the lungs and in the 
pancreas, blocking the airways, and disrupting the digestive system, 
resulting in recurrent, destructive infections and trouble digesting food. 
Respiratory failure and liver disease are the most common causes of death 
in CF.

Before now, mice have been the only animal model for CF. However since 
mice do not exhibit typical symptoms of CF, and the lung and liver 
diseases found in humans, finding a better model was crucial to furthering 
CF research.

"This represents a significant advance in research on cystic fibrosis. 
Until now, no animal model has come close to mimicking the disease as seen 
in humans. This model offers unprecedented opportunities to understand how 
the respiratory disease develops during childhood which may lead to novel 
prevention and therapeutic strategies," said Elizabeth G. Nabel, M.D., 
director, NHLBI.

"This new approach allows researchers to move beyond mouse models into 
species that are physiologically more similar to humans and that manifest 
the multi-organ symptoms of the disease. It is an advance for CF research 
as well as for the study of other diseases where the mouse model is 
inadequate," said NIDDK Director Griffin P. Rodgers, M.D.

A team of researchers from the University of Iowa and the University of 
Missouri generated male piglets lacking the CFTR gene, or possessing the 
most common mutation of the gene, which was identified in 1989. Newborn 
piglets born without CFTR had similar presentations at birth, and shortly 
after birth, as seen in human infants with CF, including typical 
abnormalities in the lungs, intestines, pancreas, and liver.



As is typical in about 15 percent of human infants with CF, newborn 
piglets without CFTR developed meconium ileus, an intestinal obstruction 
requiring corrective surgery. All of the piglets developed pancreatic 
insufficiency. The pigs also exhibited signs of focal biliary cirrhosis, 
or lesions on the liver, and gallbladder abnormalities, both typical of CF 
in humans.

Lung disease in CF is caused by infection and inflammation. Which comes 
first remains an important question for CF researchers. At birth, 
researchers found no evidence of infection or inflammation in the pigs, a 
situation similar to newborn humans with CF.

"By tracking how the lungs of these pigs respond to challenges to their 
respiratory systems introduced by the environment, we hope to better 
understand how the complications of CF progress in children," said Michael 
J. Welsh, M.D., University of Iowa and the Howard Hughes Medical 
Institute, and senior author of the study.

About 12 million Americans are carriers of an abnormal CFTR gene. Many of 
them do not know that they are CF carriers. About 30,000 people in the 
United States have CF. The median life expectancy for a person with CF is 
37 years.  Currently, there is no cure for CF, but life expectancy has 
greatly improved due to better nutrition and management of respiratory 
infections.

Additional funding for the research was provided by the Howard Hughes 
Medical Institute, Food for the 21st Century.

NIDDK conducts and supports research in diabetes and other endocrine and 
metabolic diseases; digestive diseases, nutrition, and obesity; and 
kidney, urologic, and hematologic diseases. Spanning the full spectrum of 
medicine and afflicting people of all ages and ethnic groups, these 
diseases encompass some of the most common, severe, and disabling 
conditions affecting Americans. For more information about NIDDK and its 
programs, see


http://www.niddk.nih.gov


Part of the National Institutes of Health, the National Heart, Lung, and 
Blood Institute plans, conducts, and supports research related to the 
causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, 
and blood diseases; and sleep disorders. The Institute also administers 
national health education campaigns on women and heart disease, healthy 
weight for children, and other topics. NHLBI press releases and other 
materials are available online at


<http://www.nhlbi.nih.gov>


The National Institutes of Health (NIH) -- The Nation's Medical Research 
Agency -- includes 27 Institutes and Centers and is a component of the 
U.S. Department of Health and Human Services. It is the primary federal 
agency for conducting and supporting basic, clinical and translational 
medical research, and it investigates the causes, treatments, and cures 
for both common and rare diseases. For more information about NIH and its 
programs, visit


<http://www.nih.gov>.



##


This NIH News Release is available online at:
<http://www.nih.gov/news/health/sep2008/nhlbi-25.htm>




Sincerely,
David Dillard
Temple University
(215) 204 - 4584
[log in to unmask]
Net-Gold
<http://groups.yahoo.com/group/net-gold>
<http://listserv.temple.edu/archives/net-gold.html>
<http://groups.google.com/group/net-gold>
<http://net-gold.jiglu.com/>
General Internet & Print Resources
<http://groups.yahoo.com/group/Net-Gold/message/20316>
Educational Cyberplayground
<http://www.edu-cyberpg.com/ringleaders/davidd.html>
Digital Divide Network
<http://www.digitaldivide.net/profile/jwne>
Educator-Gold
<http://groups.yahoo.com/group/Educator-Gold/>
K12ADMINLIFE
<http://groups.yahoo.com/group/K12AdminLIFE/>
Nina Dillard's Photographs on Net-Gold
<http://tinyurl.com/36qd2o>
Net-Gold Membership Required to View Photos

Top of Message | Previous Page | Permalink

Advanced Options


Options

Log In

Log In

Get Password

Get Password


Search Archives

Search Archives


Subscribe or Unsubscribe

Subscribe or Unsubscribe


Archives

April 2014
March 2014
February 2014
January 2014
December 2013
November 2013
October 2013
September 2013
August 2013
July 2013
June 2013
May 2013
April 2013
March 2013
February 2013
January 2013
December 2012
November 2012
October 2012
September 2012
August 2012
July 2012
June 2012
May 2012
April 2012
March 2012
February 2012
January 2012
December 2011
November 2011
October 2011
September 2011
August 2011
July 2011
June 2011
May 2011
April 2011
March 2011
February 2011
January 2011
December 2008
November 2008
October 2008
September 2008
August 2008
July 2008
June 2008
May 2008
April 2008
March 2008
February 2008
January 2008
December 2007
November 2007
October 2007
September 2007
August 2007
July 2007
June 2007
May 2007
April 2007
March 2007
February 2007
January 2007

ATOM RSS1 RSS2



LISTSERV.TEMPLE.EDU

CataList Email List Search Powered by the LISTSERV Email List Manager